As air pollution and respiratory diseases continue to rise, the demand for metered-dose inhalers such as Salbutamol and Terbutaline has grown rapidly. These aerosols deliver medication directly to the lungs — offering fast onset, low dosage, and targeted relief.
To meet this growing market need, manufacturers must ensure that each inhalation product is produced under strict GMP conditions, with accurate micro-dosing and contamination-free filling.
At Aile Aerosol, we provide custom-engineered filling solutions specifically designed for pharmaceutical aerosol production — combining reliability, precision, and compliance in every detail.
Understanding the Asthma Aerosol Manufacturing Process:
Asthma inhalers are complex systems consisting of:
Active ingredients such as Salbutamol sulfate or Terbutaline sulfate
Propellants (e.g., HFA-134a or HFA-227ea)
Additives including co-solvents, surfactants, and stabilizers
Each stage of production requires rigorous control to ensure product stability and consistent dose delivery.
Key Steps in MDI Production:
Container & Valve Preparation
All aluminum cans and metering valves are sterilized and dried to eliminate any risk of contamination before filling.
Formulation & Liquid Filling
Depending on the formulation type (solution, suspension, or emulsion), the drug is precisely blended and filled in controlled conditions to achieve uniformity and clarity.
Propellant Filling – Pressure or Cold Method
Pressure Filling: Propellant is injected into sealed cans at ambient temperature under controlled pressure — ideal for large-scale, efficient production.
Cold Filling: The propellant is cooled to sub-zero temperatures before filling — suitable for specific formulations but requires low-temperature systems.
Leak Testing & Final Packaging
Each filled can undergoes 100% leak and weight testing to ensure consistency, accuracy, and safety before labeling and packing.
Aile Aerosol Solutions for Pharmaceutical Aerosols:
Designed for high-precision pharmaceutical aerosol filling, the AILE-EYQWX integrates all critical functions into a single automated platform — from liquid dosing and valve placement to crimping and propellant filling.
It’s the ideal solution for continuous, high-output MDI manufacturing environments.
| Parameter | Specification |
|---|---|
| Sealing diameter(mm) | 26.5-27.5 |
| Sealing depth(mm) | 5.0-6.0 |
| Filling speed | 1200-1800 cans/h |
| Maximum liquid filling capacity | 300ml |
| Working pressure (MPa) | 0.5-0.7Mpa |
| Liquid repeat filling accuracy | ≤±1.0% |
The AILE-EYQWJ is purpose-built for new drug development, clinical trial production, and small-batch runs.
It combines liquid filling, sealing, and gas charging on one compact station — reducing manual intervention while maintaining high accuracy.
| Parameter | Specification |
|---|---|
| Material | SUS316 |
| Bottle Size | diamter35-70mm; height 80-330mm |
| Filling speed | 700-900 cans/h |
| Filling range | 30-500ml |
| Air pressure | 0.6-0.8Mpa |
| Filling Accuracy | within 1% |
Why Choose Aile Aerosol:
20+ years of experience in aerosol filling line integration
Proven expertise in pharmaceutical-grade small-dose applications
GMP and ISO certified design and manufacturing
Custom engineering support for Salbutamol, Terbutaline, and similar MDI products
End-to-end technical service — from machine setup to process validation
Whether you’re expanding your capacity or launching a new inhalation product, Aile Aerosol delivers precision-engineered equipment and turnkey solutions tailored to your pharmaceutical needs.
📩 Contact our experts today to learn more about our MDI aerosol filling systems.
👉 www.aileaerosol.com
